Paper Reading Journals #7
Utilization of precision medicine digital twins for drug discovery in Alzheimer’s disease
Basic Info
| Item | Content |
|---|---|
| Title | Utilization of precision medicine digital twins for drug discovery in Alzheimer’s disease |
| Journal | The Gerontologist |
| Author | Robert O. Morgan, Kavita R. Sail, A. Lynn Snow, et al. |
| Year Published | 2013 |
| Link | https://doi.org/10.1093/geront/gns129 |
| Geography of Study | Texas, USA |
| Area of Study | Dementia, Gerontology |
Description
(Including data and methods)
Data: 171 veterans from local VA cohort Method: Use survival analysis and path analysis and adopt regression with maximum likelihood with robust standard error estimation. Validation: Akaike Information Criterion (AIC) & Bayesian Information Criterion (BIC)
Main Contribution
(Innovative method or Application) Innovation Type: application innovation. This paper applied survival analysis to model the aggression behavior in dementia population. This is one of the early article analyze this behaviroal health problem in this approach.
Data Source
Michael E. DeBakey Veterans Affairs (VA) Medical Center with n=171, average age of 75.81 years old.
Favorite Thing
The writing strucuture and the way the present results is good for me to imitate. In addition, it also informed the power of survival analysis and path analysis in present behaviroal problems in dementia.